Anatomical Pathology
Introduction
Anatomical pathology plays a critical role in diagnosis, yet it carries a significant environmental and operational footprint. Studies from France highlight that laboratory emissions are driven largely by supply chains—especially chemicals and immunohistochemistry reagents—alongside energy-intensive equipment, transportation, and storage. At the same time, routine submission of all surgical specimens, regardless of diagnostic value, contributes to rising costs, staff workload, and unnecessary waste. In a resource-constrained healthcare system, balancing diagnostic benefit with environmental and financial impact is increasingly essential.
A shift toward evidence-based specimen management is key. Each specimen type should be evaluated for both cost (processing, storage, materials, and labour) and clinical utility (diagnostic yield, likelihood of actionable findings, and risk of missed pathology). Emerging guidelines support selective exemption of low-yield specimens from full microscopic examination, or limiting them to gross assessment only. Additional tools include reducing material retention, optimizing test utilization, recycling chemicals like formalin, and improving energy efficiency in laboratory operations.
Sustainable transformation requires coordinated governance, education, and quality assurance. Collaboration across laboratories, clinicians, and regulatory bodies enables consensus-driven policies tailored to local needs. Ongoing evaluation, shared knowledge, and staff engagement ensure that anatomical pathology services remain accurate, efficient, and environmentally responsible.
Playbook: Sustainable Anatomical Pathology
Suggested Citation:
Laurette Geldenhuys, Erica Schollenberg, Gillian Bethune, Maxine Adams-Small, Syndy Leblanc, Katherine Chornenko, Michael Bonert. Sustainable Anatomical Pathology. Version 1.0. [Internet]. CASCADES; 2025 [cited DATE]. Available from https://cascadescanada.ca/.
Supporting Resources
Formalin Recycling Circuit Protocol
Maggie Chen, Western University & London Health Sciences Centre
Formalin represents a significant source of chemical waste in pathology laboratories, with both its production and disposal carrying substantial environmental and financial costs. This resource outlines the formalin recycling methodology piloted within the Pathology and Laboratory Medicine Department at London Health Sciences Centre (LHSC). The initiative involved collecting and reusing clear formalin from surgical pathology biopsy specimens for subsequent use in the autopsy suite. Based on the results of this one-month pilot, projections indicate that expanding the protocol across all workstations for a full year could enable LHSC to save more than $3,000 annually in procurement costs while preventing 2,170 kg CO₂e emissions. By documenting and sharing this approach, we aim to support the operationalisation of sustainable waste management practices across other pathology departments and hospitals. For additional information or to request the final report and detailed results, please contact maggiee.chen@mail.utoronto.ca.
Protocol
Recommendations on practices related to tissue exemption and release
The final report, pathology early quality initiative published by the College of Physicians and Surgeons of Ontario and Cancer Care Ontario.
Guide
Anatomical pathology expired immunohistochemistry antibody use procedure
The resource provides instructions on the use of expired primary antibodies after the manufacturer’s expiry date.
Guide
Exemption of specimens from routine submission to pathology laboratories: recommendations in the Canadian context
This resource provides an overview of work on this topic, general principles and recommendations to consider and a table of specimens exempt for automatic submission to pathology laboratories in various jurisdictions.
Guide
Serous cavity fluid/bronchial washings/sputum submission guidelines
A one-page guideline for submitting cytology samples
Guide

Anatomical pathology sustainability checklist
This resource is a guideline for incorporating sustainability into anatomical pathology laboratories.
Checklist






