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This playbook introduces the SE-QI framework and provides background information, resources, and considerations for embedding sustainability in healthcare improvement projects. It was developed in collaboration with key partners and experts in QI across Canada. It serves as a resource for clinicians, health care professionals, students, trainees, and decision-makers involved in QI work, aiming to inform them of: Sustainability-Embedded Quality Improvement (SE-QI) positions quality improvement (QI) as a practical pathway for embedding sustainability within clinical and operational practice. This playbook introduces the SE-QI framework and provides background information, resources, and considerations for embedding sustainability in healthcare improvement projects. It was developed in collaboration with key partners and experts in QI across Canada. It serves as a resource for clinicians, health care professionals, students, trainees, and decision-makers involved in QI work, aiming to inform them of: Why SE-QI is an essential and practical approach to quality improvement in healthcare, What tools are available to support planning and implementation, and how to effectively implement SE-QI into practice to advance high-quality, low-carbon, resilient healthcare.